Chronic psychological stress suppresses activity in the prefrontal cortex and periaqueductal gray, triggering a downstream depletion of gut Lactobacillus reuteri and its anti-aging metabolite spermidine. This biochemical crash directly accelerates the aging of hematopoietic stem cells in the bone marrow, mapping a novel brain-gut-bone axis for stress-induced immune decay.
Chronic psychological stress suppresses activity in the prefrontal cortex and periaqueductal gray, triggering a downstream depletion of gut Lactobacillus reuteri and its anti-aging metabolite spermidine. This biochemical crash directly accelerates the aging of hematopoietic stem cells in the bone marrow, mapping a novel brain-gut-bone axis for stress-induced immune decay.
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